Table 3 Comparisons between patients with or without a K-ras or APC mutation and hMLH1 expression.
Genetic aberration | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
APC a | K-ras b | hMLH1 expression | ||||||||||
No mutation (truncation) | Mutation (truncation) | No mutation (codon 12/13) | Mutation (codon 12/13) | Present | Absent | |||||||
Number of patients (%) | 411 | (63) | 245 | (37) | 421 | (64) | 235 | (36) | 598 | (91) | 58 | (9) |
Age at diagnosis (yr, mean (SD)) | 68.2 | (4.3) | 67.5 | (4.2) | 67.7 | (4.3) | 68.3 | (4.3) | 67.9 | (4.2) | 68.7 | (4.7) |
P-value | 0.07 | 0.08 | 0.18 | |||||||||
Sex (% male) | 54 | 58 | 56 | 55 | 57 | 45 | ||||||
P-value | 0.45 | 0.84 | 0.08 | |||||||||
Family history of colorectal cancer (% yes) | 10 | 9 | 11 | 7 | 10 | 9 | ||||||
P-value | 0.89 | 0.07 | 0.79 | |||||||||
Tumour sub-localisationc | ||||||||||||
Proximal colon | 151 | (69%) | 67 | (31%) | 141 | (65%) | 77 | (35%) | 169 | (78%) | 49 | (12%) |
Distal colon | 138 | (68%) | 66 | (32%) | 144 | (71%) | 60 | (29%) | 199 | (98%) | 5 | (2%) |
Rectosigmoid | 34 | (47%) | 39 | (53%) | 44 | (60%) | 29 | (40%) | 73 | (100%) | 0 | (0%) |
Rectum | 83 | (55%) | 67 | (45%) | 85 | (57%) | 65 | (43%) | 146 | (97%) | 4 | (3%) |
P-value | <0.001 | 0.05 | <0.001 | |||||||||
Dukes' stagec | ||||||||||||
A | 94 | (60%) | 63 | (40%) | 103 | (66%) | 54 | (34%) | 142 | (90%) | 15 | (10%) |
B | 147 | (67%) | 73 | (33%) | 142 | (65%) | 78 | (35%) | 192 | (87%) | 28 | (13%) |
C | 97 | (60%) | 64 | (40%) | 107 | (66%) | 54 | (34%) | 151 | (94%) | 10 | (6%) |
D | 39 | (54%) | 33 | (46%) | 40 | (56%) | 32 | (44%) | 69 | (96%) | 3 | (4%) |
P-value | 0.21 | 0.42 | 0.07 | |||||||||
Differentiationc | ||||||||||||
Good | 35 | (56%) | 28 | (44%) | 40 | (63%) | 23 | (37%) | 59 | (94%) | 4 | (6%) |
Moderate | 250 | (62%) | 156 | (38%) | 258 | (64%) | 148 | (34%) | 380 | (94%) | 26 | (6%) |
Poor | 66 | (69%) | 30 | (31%) | 68 | (71%) | 28 | (29%) | 82 | (85%) | 14 | (15%) |
Undifferentiated | 6 | (86%) | 1 | (14%) | 5 | (71%) | 2 | (29%) | 4 | (57%) | 3 | (43%) |
P-value | 0.20 | 0.57 | <0.001 | |||||||||