Skip to main content

Table 3 Comparisons between patients with or without a K-ras or APC mutation and hMLH1 expression.

From: Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study

  Genetic aberration
  APC a K-ras b hMLH1 expression
  No mutation
(truncation)
Mutation
(truncation)
No mutation
(codon 12/13)
Mutation
(codon 12/13)
Present Absent
Number of patients (%) 411 (63) 245 (37) 421 (64) 235 (36) 598 (91) 58 (9)
Age at diagnosis (yr, mean (SD)) 68.2 (4.3) 67.5 (4.2) 67.7 (4.3) 68.3 (4.3) 67.9 (4.2) 68.7 (4.7)
   P-value 0.07 0.08 0.18
Sex (% male) 54   58 56   55   57   45  
   P-value 0.45 0.84 0.08
Family history of colorectal cancer (% yes) 10   9 11   7   10   9  
   P-value 0.89 0.07 0.79
Tumour sub-localisationc             
   Proximal colon 151 (69%) 67 (31%) 141 (65%) 77 (35%) 169 (78%) 49 (12%)
   Distal colon 138 (68%) 66 (32%) 144 (71%) 60 (29%) 199 (98%) 5 (2%)
   Rectosigmoid 34 (47%) 39 (53%) 44 (60%) 29 (40%) 73 (100%) 0 (0%)
   Rectum 83 (55%) 67 (45%) 85 (57%) 65 (43%) 146 (97%) 4 (3%)
   P-value <0.001 0.05 <0.001
Dukes' stagec             
   A 94 (60%) 63 (40%) 103 (66%) 54 (34%) 142 (90%) 15 (10%)
   B 147 (67%) 73 (33%) 142 (65%) 78 (35%) 192 (87%) 28 (13%)
   C 97 (60%) 64 (40%) 107 (66%) 54 (34%) 151 (94%) 10 (6%)
   D 39 (54%) 33 (46%) 40 (56%) 32 (44%) 69 (96%) 3 (4%)
   P-value 0.21 0.42 0.07
Differentiationc             
   Good 35 (56%) 28 (44%) 40 (63%) 23 (37%) 59 (94%) 4 (6%)
   Moderate 250 (62%) 156 (38%) 258 (64%) 148 (34%) 380 (94%) 26 (6%)
   Poor 66 (69%) 30 (31%) 68 (71%) 28 (29%) 82 (85%) 14 (15%)
   Undifferentiated 6 (86%) 1 (14%) 5 (71%) 2 (29%) 4 (57%) 3 (43%)
   P-value 0.20 0.57 <0.001
  1. a APC mutations: only mutations resulting in a stop codon.
  2. b K-ras mutations: only activating mutations in codon 12 or 13.
  3. c Tumour sublocalisation, Dukes's stage and differentiation gave rise to missing values.