Patienta | Sex | Age at diagnosis (yr) | Sub-localisation | Dukes' stage | Tumour differentiation | Codon | Mutation | Amino acid change | hMLH1 expressionb | Truncating APC mutationb | Activating K-ras mutation |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | M | 65 | Proximal colon | B | Moderate | 37 | C→T | Ser→Phe | Present | No | Yes |
2 | M | 67 | Proximal colon | A | Moderate | 45 | C→T | Ser→Phe | Absent | No | Yes |
3 | M | 69 | Proximal colon | B | Good | 45 | C→T | Ser→Phe | Absent | No | No |
4 | M | 61 | Proximal colon | C | Moderate | 45 | C→T | Ser→Phe | Present | No | Yes |
5 | F | 69 | Proximal colon | A | Undifferentiated | 45 | C→T | Ser→Phe | Absent | No | Yes |
6c | M | 69 | Distal colon | B | Moderate | 22 | G→A | Val→Ile | Present | No | Yes |
7c | F | 65 | Proximal colon | A | Moderate | 29 | C→A | Ser→Tyr | Present | No | No |