Patienta
|
Sex
|
Age at diagnosis (yr)
|
Sub-localisation
|
Dukes' stage
|
Tumour differentiation
|
Codon
|
Mutation
|
Amino acid change
|
hMLH1 expressionb
|
Truncating APC mutationb
|
Activating K-ras mutation
|
---|
1
|
M
|
65
|
Proximal colon
|
B
|
Moderate
|
37
|
C→T
|
Ser→Phe
|
Present
|
No
|
Yes
|
2
|
M
|
67
|
Proximal colon
|
A
|
Moderate
|
45
|
C→T
|
Ser→Phe
|
Absent
|
No
|
Yes
|
3
|
M
|
69
|
Proximal colon
|
B
|
Good
|
45
|
C→T
|
Ser→Phe
|
Absent
|
No
|
No
|
4
|
M
|
61
|
Proximal colon
|
C
|
Moderate
|
45
|
C→T
|
Ser→Phe
|
Present
|
No
|
Yes
|
5
|
F
|
69
|
Proximal colon
|
A
|
Undifferentiated
|
45
|
C→T
|
Ser→Phe
|
Absent
|
No
|
Yes
|
6c
|
M
|
69
|
Distal colon
|
B
|
Moderate
|
22
|
G→A
|
Val→Ile
|
Present
|
No
|
Yes
|
7c
|
F
|
65
|
Proximal colon
|
A
|
Moderate
|
29
|
C→A
|
Ser→Tyr
|
Present
|
No
|
No
|
-
a Tumours of 464 sporadic colorectal cancer patients were analysed.
-
b 58 Tumours were selected based on absence of hMLH1 expression, 411 tumours studied were selected based on absence of a truncating APC mutation.
-
c Two patients (numbers 6 and 7) harboured a CTNNB1 mutation that would not lead to loss of a known phosphorylation site.