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Table 1 Description of patient, tumour and molecular characteristics of colorectal cancers harbouring a CTNNB1 mutation.

From: Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study

Patienta Sex Age at diagnosis (yr) Sub-localisation Dukes' stage Tumour differentiation Codon Mutation Amino acid change hMLH1 expressionb Truncating APC mutationb Activating K-ras mutation
1 M 65 Proximal colon B Moderate 37 C→T Ser→Phe Present No Yes
2 M 67 Proximal colon A Moderate 45 C→T Ser→Phe Absent No Yes
3 M 69 Proximal colon B Good 45 C→T Ser→Phe Absent No No
4 M 61 Proximal colon C Moderate 45 C→T Ser→Phe Present No Yes
5 F 69 Proximal colon A Undifferentiated 45 C→T Ser→Phe Absent No Yes
6c M 69 Distal colon B Moderate 22 G→A Val→Ile Present No Yes
7c F 65 Proximal colon A Moderate 29 C→A Ser→Tyr Present No No
  1. a Tumours of 464 sporadic colorectal cancer patients were analysed.
  2. b 58 Tumours were selected based on absence of hMLH1 expression, 411 tumours studied were selected based on absence of a truncating APC mutation.
  3. c Two patients (numbers 6 and 7) harboured a CTNNB1 mutation that would not lead to loss of a known phosphorylation site.