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Table 2 Exposures to ≥ 90 days of COX-2 inhibitors, ns-NSAIDs, aspirin and acetaminophen in the year prior to the index date: Crude and adjusted odds ratios.

From: Association between frequent use of nonsteroidal anti-inflammatory drugs and breast cancer

Exposure to ≥ 90 days Cases N of patients (%) Controls N of patients (%) Crude odds ratios Adjusted odds ratios*
Ns-NSAID/COX-2 inhibitors 186 (17.1) 8,681 (19.3) 0.70 (0.59, 0.84) 0.75 (0.64, 0.89)
COX-2 inhibitors 166 (15.2) 7,412 (16.5) 0.73 (0.61, 0.88) 0.81 (0.68, 0.97)
   Rofecoxib 76 (7.0) 3,597 (8.0) 0.69 (0.54, 0.89) 0.80 (0.63, 1.02)
   Celecoxib 93 (8.5) 3,792 (8.4) 0.80 (0.64, 1.00) 0.88 (0.70, 1.10)
Ns-NSAIDs 24 (2.2) 1,278 (2.8) 0.61 (0.40, 0.93) 0.65 (0.43, 0.99)
Aspirin     
   average daily dose ≤ 100 mg/day 78 (7.2) 2,894 (6.4) 0.88 (0.69, 1.13) 0.91 (0.71, 1.16)
   average daily dose >100 mg/day# 211 (19.4) 8,419 (18.7) 0.82 (0.69, 0.97) 0.75 (0.64, 0.89)
Acetaminophen 74 (6.8) 2,534 (5.6) 0.95 (0.74, 1.23) 0.91 (0.71, 1.16)
Not exposed § 375 (34.4) 12,260 (27.3) 1 (Reference) 1(Reference)
  1. * Adjusted for age, mammography in years 2 or 3 prior to index date, breast procedure in the prior 3 years, benign neoplasm of the breast in the prior 3 years, other breast disease in the prior 3 years, estrogen replacement therapy in the prior year, and visit to a gynecologist in the prior year- these variables were risk factors for breast cancer but their inclusion in the model did not alter substantially the effect of exposure to the drugs of interest.
  2. #90% of all aspirin prescriptions were for ≤ 325 mg/day
  3. §Not exposed refers to the group of patients who were not exposed to ns-NSAIDs, aspirin, COX-2 inhibitors or acetaminophen during the year prior to the index date
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