From: Association between frequent use of nonsteroidal anti-inflammatory drugs and breast cancer
 | Cases (%) | Controls (%) |
---|---|---|
Number of patients | 1,090 | 44,990 |
Mean age at index date ± SD | 74.1 ± 5.7 | 71.1 ± 4.3 |
   Number of patients 66–74 | 670 (61.5) | 36,900 (82.0) |
   Number of patients 75–84 | 369 (33.9) | 7,665 (17.0) |
   Number of patients ≥ 85 | 51 (0.05) | 425 (0.9) |
Risk factors | Â | Â |
   Mammography in years 2 or 3 prior to the index date | 514 (47.2) | 35,229 (78.3) |
   History of diagnostic and therapeutic breast procedures in the 3 prior to the index date | 19 (1.7) | 296 (0.7) |
   Benign neoplasm of the breast in the 3 years prior to the index date | 15 (1.4) | 319 (0.7) |
   Other breast disease in the 3 years prior to the index date | 169 (15.5) | 4,667 (10.4) |
   Estrogen replacement therapy in the year prior to the index date | 299 (27.4) | 17,837 (39.7) |
   Combined estrogen/progesterone therapy in the year prior to the index date | 101 (9.3) | 4,943 (11.0) |
Visit to a gynecologist in the year prior to the index date | 152 (13.9) | 10,076 (22.4) |
Exposure to the drugs of interest (one or more prescriptions in the year prior to the index date) | Â | Â |
   Ns-NSAID/COX-2 inhibitors | 443 (40.6) | 22,126 (49.2) |
Ns-NSAIDs | 102 (9.4) | 5,572 (12.4) |
COX-2 inhibitors | 388 (35.8) | 19,228 (42.7) |
Rofecoxib | 242 (22.2) | 11,498 (25.6) |
Celecoxib | 203 (18.6) | 10,269 (22.8) |
   Aspirin | 329 (30.2) | 13,391 (29.8) |
   Acetaminophen | 253 (23.2) | 10,159 (22.6) |
   Not exposed* | 375 (34.4) | 12,260 (27.3) |