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Table 1 Patient characteristics at the index date and mortality in the following 6 months

From: Association between frequent use of nonsteroidal anti-inflammatory drugs and breast cancer

 

Cases (%)

Controls (%)

Number of patients

1,090

44,990

Mean age at index date ± SD

74.1 ± 5.7

71.1 ± 4.3

   Number of patients 66–74

670 (61.5)

36,900 (82.0)

   Number of patients 75–84

369 (33.9)

7,665 (17.0)

   Number of patients ≥ 85

51 (0.05)

425 (0.9)

Risk factors

  

   Mammography in years 2 or 3 prior to the index date

514 (47.2)

35,229 (78.3)

   History of diagnostic and therapeutic breast procedures in the 3 prior to the index date

19 (1.7)

296 (0.7)

   Benign neoplasm of the breast in the 3 years prior to the index date

15 (1.4)

319 (0.7)

   Other breast disease in the 3 years prior to the index date

169 (15.5)

4,667 (10.4)

   Estrogen replacement therapy in the year prior to the index date

299 (27.4)

17,837 (39.7)

   Combined estrogen/progesterone therapy in the year prior to the index date

101 (9.3)

4,943 (11.0)

Visit to a gynecologist in the year prior to the index date

152 (13.9)

10,076 (22.4)

Exposure to the drugs of interest (one or more prescriptions in the year prior to the index date)

  

   Ns-NSAID/COX-2 inhibitors

443 (40.6)

22,126 (49.2)

Ns-NSAIDs

102 (9.4)

5,572 (12.4)

COX-2 inhibitors

388 (35.8)

19,228 (42.7)

Rofecoxib

242 (22.2)

11,498 (25.6)

Celecoxib

203 (18.6)

10,269 (22.8)

   Aspirin

329 (30.2)

13,391 (29.8)

   Acetaminophen

253 (23.2)

10,159 (22.6)

   Not exposed*

375 (34.4)

12,260 (27.3)

  1. SD – standard deviation
  2. *Not exposed refers to the group of patients who were not exposed to ns-NSAIDs, aspirin, COX-2 inhibitors or acetaminophen during the year prior to the index date