Figure 5

Immunohistochemical localization of cIAP-2/BIRC3. Photomicrographs of normal bronchial epithelium (A), mild dysplasia (B), severe dysplasia (C) and a negative control processed without primary antibody (D). In normal and mild dysplasia, perinuclear staining was observed, predominantly in cells adjacent to the basement membrane (for example, arrow in panel B). Increased staining intensity and increased frequency of nuclear staining was observed in severe dysplasias (panel C).