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Table 4 Association between parental ages at birth and risk of breast cancer in daughters after stratified by menopause status

From: Association of paternal age at birth and the risk of breast cancer in offspring: a case control study

Age at birth of the subjects (yrs) Cases (%) Controls (%) OR (95% CI)1 OR (95% CI)2
Premenopause     
Paternal age     
Mean ± SD 33.7 ± 7.0 32.9 ± 6.6 1.16 (0.98–1.38)  
<30 183 (31.6) 210 (36.3) 1.0 1.0
30–34 162 (28.0) 161 (27.8) 1.1 (0.85–1.54) 1.1 (0.76–1.50)
35–39 108 (18.7) 105 (18.1) 1.1 (0.82–1.60) 1.2 (0.77–1.85)
≥40 126 (21.8) 103 (17.8) 1.4 (1.00–1.93) 1.9 (1.12–3.26)
P for trend    0.062 0.031
Maternal age     
Mean ± SD 29.1 ± 5.8 28.8 ± 6.1 1.06 (0.87–1.29)  
<25 133 (23.0) 159 (27.5) 1.0 1.0
25–29 194 (33.5) 187 (32.3) 1.3 (0.93–1.73) 1.2 (0.86–1.70)
30–34 147 (25.4) 120 (20.7) 1.5 (1.06–2.07) 1.2 (0.78–1.88)
≥35 105 (18.1) 113 (19.5) 1.1 (0.76–1.55) 0.7 (0.38–1.15)
P for trend    0.363 0.361
Postmenopause     
Paternal age     
Mean ± SD 32.2 ± 8.1 31.8 ± 8.0 1.11 (0.94–1.32)  
<30 179 (41.4) 190 (44.0) 1.0 1.0
30–34 104 (24.1) 100 (23.2) 1.2 (0.82–1.65) 1.0 (0.66–1.48)
35–39 61 (14.1) 69 (16.0) 1.0 (0.65–1.49) 0.8 (0.47–1.35)
≥40 88 (20.4) 73 (16.9) 1.4 (0.94–2.03) 1.2 (0.66–2.29)
P for trend    0.173 0.804
Maternal age     
Mean ± SD 28.2 ± 7.1 27.7 ± 6.9 1.16 (0.95–1.41)  
<25 152 (35.2) 171 (39.6) 1.0 1.0
25–29 108 (25.0) 110 (25.5) 1.1 (0.80–1.60) 1.2 (0.80–2.29)
30–34 90 (20.8) 72 (16.7) 1.6 (1.05–2.31) 1.6 (0.97–2.69)
≥35 82 (19.0) 79 (18.3) 1.2 (0.82–1.78) 1.1 (0.58–2.03)
P for trend    0.112 0.415
  1. 1OR adjusted for family history of breast cancer in 1st or 2nd degree relatives and lifetime estrogen exposure duration
  2. 2OR adjusted for maternal age or paternal age (mutual parental age, categorical value) in addition to the variables in the model 1
  3. OR per 10 year