TY - JOUR AU - Mullins, D'Anna N. AU - Crawford, Erin L. AU - Khuder, Sadik A. AU - Hernandez, Dawn-Alita AU - Yoon, Youngsook AU - Willey, James C. PY - 2005 DA - 2005/10/29 TI - CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma JO - BMC Cancer SP - 141 VL - 5 IS - 1 AB - Cigarette smoking is the primary cause of bronchogenic carcinoma (BC), yet only 10–15% of heavy smokers develop BC and it is likely that this variation in risk is, in part, genetically determined. We previously reported a set of antioxidant genes for which transcript abundance was lower in normal bronchial epithelial cells (NBEC) of BC individuals compared to non-BC individuals. In unpublished studies of the same NBEC samples, transcript abundance values for several DNA repair genes were correlated with these antioxidant genes. From these data, we hypothesized that antioxidant and DNA repair genes are co-regulated by one or more transcription factors and that inter-individual variation in expression and/or function of one or more of these transcription factors is responsible for inter-individual variation in risk for BC. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-5-141 DO - 10.1186/1471-2407-5-141 ID - Mullins2005 ER -