Skip to main content

Table 4 Transcriptional regulation: global and targeted

From: Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells

Gene Symbol (Probe)

Name

†Fold change (qRT-PCR)

Rank

Function/Other information

ANC 2H01/ZNF639/ZASC1

Zinc finger protein 639

1.3 (ND)

76

Kruppel domain

CITED4

CPB/p300-binding protein & interacting 4

1.3 (ND)

74

Transcriptional coactivator

FJL23577

Hypothetical, Kruppel-like protein

-1.8 (NC)

10

Unknown

HIPK2

Homeodomain-p53-interacting protein

-1.4 (ND)

51

Homeodomain interacting protein kinase 2

HOXB7

Homeobox gene B7 (ANTP family)

-1.4 (-1.2)

38

Inhibits differentiation

*JUN

cJUN

-1.3 (-1.5)

90

AP1 complex

KIAA115

SIT4 phosphatase-associated protein-like

-1.3 (ND)

82

Cyclin/G1 transcription

MGC15737/TCEAL3

Transcription elongation factor A-like 3

1.3 (ND)

100

Transcriptional elongation

ZNF387, ST18

Zinc finger protein 387; breast cancer suppressor of tumorigenicity

1.6 (2.7)

20

Transcription/Tumor suppressor (see also Table 2)

  1. †"Fold change," top number is the relative expression of RARβ2 transduced cells/empty vector control cells from Agilent arrays. The number in parentheses is the relative expression of the same cells from qRT-PCR analysis, normalized by respective qRT-PCR RPLP0 expression
  2. ND = not done
  3. NC = not confirmed, has at least two isoforms that overlap the 60-mer probe
  4. * "cross-talks" with RARs