Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells

Table 2 Gene cluster on Xq28

Gene Symbol (Probe)	Name	†Fold change (qRT-PCR)	Rank	Function/Other information
ARHGAP4	Rho-GAP GTPase	1.4 (2.2)	44	Possible inhibitory role on stress fiber organization and microtubules
§CTAG1	Cancer/testis antigen 1	2.2 (1.6)	3
§CTAG2	Cancer/testis antigen 2	1.3 (1.6)	93
§ *LOC389903	Cancer antigen	1.3 (NC)	75
§ **MAGEA2	Cancer antigen	1.3 (NC)	73
RPL10	Ribosomal protein	1.6 (1.4)	22	Tumor suppressor
SSR4	Signal sequence receptor/translocon associated protein delta	1.4 (1.2)	52	Type I receptor in endoplasmic reticulum/intracellular protein transport
§ *TRAG3	Tumor antigen	1.3 (NC)	77

† "Fold change," top number is the relative expression of RARβ2 transduced cells/empty vector control cells from Agilent arrays. The number in parentheses is the relative expression of the same cells from qRT-PCR analysis, normalized by respective qRT-PCR RPLP0 expression.
NC = differential expression was not confirmed by qRT-PCR
§ Genes in the cancer/testis antigen superfamily
* Shares significant overlapping sequence within their respective 60 mer probes, differing by 2–3 nucleotides
** MAGEA2 60 mer probe shares significant sequence identity with MAGEA-3, -6, and -12 (differs by 1–2 nucleotides)

ISSN: 1471-2407