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Table 2 Gene cluster on Xq28

From: Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells

Gene Symbol (Probe) Name †Fold change (qRT-PCR) Rank Function/Other information
ARHGAP4 Rho-GAP GTPase 1.4 (2.2) 44 Possible inhibitory role on stress fiber organization and microtubules
§CTAG1 Cancer/testis antigen 1 2.2 (1.6) 3  
§CTAG2 Cancer/testis antigen 2 1.3 (1.6) 93  
§ *LOC389903 Cancer antigen 1.3 (NC) 75  
§ **MAGEA2 Cancer antigen 1.3 (NC) 73  
RPL10 Ribosomal protein 1.6 (1.4) 22 Tumor suppressor
SSR4 Signal sequence receptor/translocon associated protein delta 1.4 (1.2) 52 Type I receptor in endoplasmic reticulum/intracellular protein transport
§ *TRAG3 Tumor antigen 1.3 (NC) 77  
  1. † "Fold change," top number is the relative expression of RARβ2 transduced cells/empty vector control cells from Agilent arrays. The number in parentheses is the relative expression of the same cells from qRT-PCR analysis, normalized by respective qRT-PCR RPLP0 expression.
  2. NC = differential expression was not confirmed by qRT-PCR
  3. § Genes in the cancer/testis antigen superfamily
  4. * Shares significant overlapping sequence within their respective 60 mer probes, differing by 2–3 nucleotides
  5. ** MAGEA2 60 mer probe shares significant sequence identity with MAGEA-3, -6, and -12 (differs by 1–2 nucleotides)
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