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Figure 3 | BMC Cancer

Figure 3

From: Numbers of mutations to different types of colorectal cancer

Figure 3

Multistage versus tumor progression models. In multistage models, early mutations fail to confer visible changes in phenotype because they accumulate throughout life from birth. Tumors appear only after a cell has accumulated a critical number or combination of oncogenic mutations. In contrast, the adenoma-cancer sequence suggests most oncogenic mutations confer stepwise incremental changes in phenotype and accumulate much later in life in visible tumors.

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