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Table 4 Number of risk-genotypes of three DNA repair genes and colorectal cancer risk by age at diagnosis and by tumor site

From: Polymorphisms of the XRCC1, XRCC3, & XPDgenes, and colorectal cancer risk: a case-control study in Taiwan

  Number of risk-genotypes*  
  0 1 2 3 Pb
Age at diagnosis      
< = 60 years      
Cases/Controls 7/20 114/126 169/155 29/17  
OR 1.0 2.58 3.12 4.90 0.004
(95% CI)a (reference) (1.05–6.33) (1.28–7.58) (1.72–14.0)  
>60 years      
Cases/Controls 11/14 161/167 198/203 25/25  
OR 1.0 1.24 1.25 1.28 0.74
(95% CI)a (reference) (0.55–2.82) (0.55–2.83) (0.49–3.35)  
Tumor site      
Colon      
Cases/Controls 10/34 132/293 177/358 23/42  
OR 1.0 1.51 1.65 1.86 0.16
(95% CI)a (reference) (0.72–3.14) (0.80–3.42) (0.78–4.44)  
Rectum      
Cases/Controls 8/34 143/293 190/358 31/42  
OR 1.0 2.13 2.32 3.18 0.03
(95% CI)a (reference) (0.96–4.73) (1.05–5.11) (1.29–7.82)  
  1. *Risk-genotype was defined as genotype with OR>1 as shown in Table 3.
  2. a: ORs and 95% CIs were estimated from unconditional logistic regressions, controlling for age and gender
  3. b: p for trend test