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Table 2 Chymotryptic 20S Proteasome Activity in Lysates from ECV 304 Cells

From: Anthracyclines, proteasome activity and multi-drug-resistance

μM

Doxorubincin

Daunorubicin

Epirubicin

Idarubicin

0

1

1

1

1

6.25

0.49 ± 0.1*

0.62 ± 0.19 n.s.

0.71 ± 0.21 n.s.

0.67 ± 0.07*

12.5

0.28 ± 0.09**

0.64 ± 0.07 n.s.

0.46 ± 0.2 n.s.

0.67 ± 0.08*

25

0.28 ± 0.13*

0.81 ± 0.05 n.s.

0.37 ± 0.08**

0.69 ± 0.05**

50

0.24 ± 0.06**

0.95 ± 0.04 n.s.

0.33 ± 0.07**

0.67 ± 0.05 **

100

0.25 ± 0.07**

1.05 ± 0.1 n.s.

0.35 ± 0.07**

0.49 ± 0.11*

  1. n.s. not significant, *p < 0.05, **p < 0.01, ***p < 0.001 (two-sided student's t-test)