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Table 2 Chymotryptic 20S Proteasome Activity in Lysates from ECV 304 Cells

From: Anthracyclines, proteasome activity and multi-drug-resistance

μM Doxorubincin Daunorubicin Epirubicin Idarubicin
0 1 1 1 1
6.25 0.49 ± 0.1* 0.62 ± 0.19 n.s. 0.71 ± 0.21 n.s. 0.67 ± 0.07*
12.5 0.28 ± 0.09** 0.64 ± 0.07 n.s. 0.46 ± 0.2 n.s. 0.67 ± 0.08*
25 0.28 ± 0.13* 0.81 ± 0.05 n.s. 0.37 ± 0.08** 0.69 ± 0.05**
50 0.24 ± 0.06** 0.95 ± 0.04 n.s. 0.33 ± 0.07** 0.67 ± 0.05 **
100 0.25 ± 0.07** 1.05 ± 0.1 n.s. 0.35 ± 0.07** 0.49 ± 0.11*
  1. n.s. not significant, *p < 0.05, **p < 0.01, ***p < 0.001 (two-sided student's t-test)
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