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Table 1 Chymotryptic 26S Proteasome Activity in Lysates from ECV 304 Cells

From: Anthracyclines, proteasome activity and multi-drug-resistance

μM Doxorubincin Daunorubicin Epirubicin Idarubicin
0 1 1 1 1
6.25 0.92 ± 0.03* 0.85 ± 0.05* 0.79 ± 0.1 n.s. 0.97 ± 0.03 n.s.
12.5 0.84 ± 0.05* 0.53 ± 0.11* 0.57 ± 0.31 n.s. 0.96 ± 0.02 n.s.
25 0.72 ± 0.04** 0.22 ± 0.09** 0.59 ± 0.14* 0.79 ± 0.12 n.s.
50 0.59 ± 0.1* 0.12 ± 0.06** 0.36 ± 0.2* 0.28 ± 0.09 **
100 0.36 ± 0.03*** 0.11 ± 0.06** 0.27 ± 0.17* 0.1 ± 0.06 **
  1. n.s. not significant, *p < 0.05, **p < 0.01, ***p < 0.001 (two-sided student's t-test)
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