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Figure 3 | BMC Cancer

Figure 3

From: Anthracyclines, proteasome activity and multi-drug-resistance

Figure 3

MG-132 treatment of KB 8-5 causes intracellular accumulation of anthracyclines. Incubation of KB 8-5 cells, which overexpress P-gp, with increasing doses of MG-132 (0, 6.25, 12.5, 25, 50 μM) caused a dose-dependent accumulation of daunorubicin, as measured by fluorescence, indicating inhibition of P-gp function by this proteasome inhibitor.

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