From: Phosphorylation states of cell cycle and DNA repair proteins can be altered by the nsSNPs
Pathway | Gene | nsSNP | Possible effect on phosphorylation | Frequency | Functional analysis | Cancer risk association |
---|---|---|---|---|---|---|
DNA repair | BRCA1 | P871L | Abolishes at S869 | 2 | - | - |
 | ERCC4 | P379S | Creates at S379 | 1 and 2 | - | - |
 | IGHMBP2 | T671A | Abolishes at S672 | 2 | - | - |
 | OGG1 | S326C | Abolishes at S326 | 2 | Yamane et al. [55] | Sugimura et al. [52]; Xing et al. [53]; Elahi et al. [54] |
 | XRCC3 | T241M | Abolishes and T241 | 2 | Yoshihara et al. [51] | Winsey et al. [49]; Kuschel et al. [47]; Shen et al. [50]; Figueiredo et al. [48] |
Cell cycle | CCND3 | S259A | Abolishes at S359 | 2 | - | - |
 | CDKN1A | S31R | Abolishes at S31 | 2 | Chedid et al. [59] | Wu et al. [58]; Roh et al. [56]; Tsai et al. [57] |