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Table 1 Resistance to ionising irradiation and cytotoxic drugs in relation to the p53 codon 72 status

From: In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis

 

all patients

 

p53 wild type

 
 

p53 codon 72 Arg/Arg

p53 codon 72 Pro/Pro

p53 codon 72 Arg/Pro

p

p53 codon 72 Arg/Arg

p53 codon 72 Pro/Pro

p53 codon 72 Arg/Pro

p

γ-irradiation

(% surviving cells)

36.3 ± 4.7

(n = 49)

50.0 ± 10.1

(n = 7)

24.2 ± 4.8

(n = 26)

0.099

30.6 ± 4.8

(n = 39)

54.7 ± 13.4

(n = 5)

22.9 ± 4.9

(n = 25)

0.14

log10 LC90 chlorambucil

0.73 ± 0.07

(n = 78)

0.76 ± 0.19

(n = 9)

0.62 ± 0.08

(n = 49)

0.63

0.6 ± 0.08

(n = 61)

0.76 ± 0.22

(n = 7)

0.57 ± 0.08

(n = 46)

0.70

log10 LC90 mafosfamide

0.32 ± 0.05

(n = 75)

0.37 ± 0.12

(n = 9)

0.21 ± 0.05

(n = 47)

0.39

0.3 ± 0.06

(n = 59)

0.38 ± 0.16

(n = 7)

0.21 ± 0.05

(n = 44)

0.42

log10 LC90 fludarabine

0.18 ± 0.08

(n = 78)

0.13 ± 0.18

(n = 9)

-0.32 ± 0.1

(n = 49)

0.32

0.11 ± 0.1

(n = 61)

0.22 ± 0.23

(n = 7)

-0.06 ± 0.01

(n = 46)

0.28

log10 LC90 cladribine

-0.76 ± 0.1

(n = 78)

-0.85 ± 0.18

(n = 9)

-1.0 ± 0.11

(n = 49)

0.10

-0.89 ± 0.1

(n = 61)

-0.79 ± 0.22

(n = 7)

-1.04 ± 0.11

(n = 46)

0.22

log10 LC90 vincristine

0.13 ± 0.1

(n = 55)

0.01 ± 0.27

(n = 8)

-0.22 ± 0.11

(n = 39)

0.71

-0.14 ± 0.11

(n = 40)

0.05 ± 0.33

(n = 6)

-0.25 ± 0.11

(n = 36)

0.59

log10 LC90 doxorubicin

-0.55 ± 0.04

(n = 78)

-0.52 ± 0.06

(n = 9)

-0.61 ± 0.05

(n = 49)

0.64

-0.55 ± 0.05

(n = 61)

-0.49 ± 0.07

(n = 7)

-0.63 ± 0.05

(n = 46)

0.35

log10 LC90 methylprednisolone

0.99 ± 0.14

(n = 78)

1.36 ± 0.45

(n = 9)

0.95 ± 0.18

(n = 48)

0.70

0.99 ± 0.16

(n = 61)

1.52 ± 0.47

(n = 7)

0.95 ± 0.18

(n = 45)

0.57

  1. For the cytostatic drugs (chlorambucil, mafosfamide, fludarabine, cladribine, vincristine, doxorubicin or methylprednisolone) log10 LC90 concentrations were compared. In case of ionizing γ-irradiation with a fixed dose of 2 Gy, percentages of surviving cells were compared. p53 WT: wild type p53 gene. Mean +/- SEM is given. Statistical significance was calculated by means of the Kruskal-Wallis test.