Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors

BMC Cancer

Table 4 mtDNA alterations in human brain tumors compared to matched tissue controls

Type of tumor	Number of tumors	Number of tumors with mtDNA somatic mutations^a	Number of somatic mutations causing amino acid substitutions^c	Region of mutation	Reference
Neurofibroma	37	23/37	NA^d	D-loop	Kurtz et al. 2004
Glioma	53	20/53	NA	HVRII	Vega et al. 2004
Meningioma	11	5/11	NA
Schwannoma	5	1/5	NA
Medulloblastoma	15	6/15	2/18	D-loop, Asp tRNA, COXI, CoxII, Thr tRNA, ND4	Wong et al. 2003
Gliomatosis cerebri	6	2/6	NA	HVRII	Kirches et al. 2003
Glioma	55	12/55	NA	HVRII, D-loop	Kirches et al. 2001
Astrocytoma	12	11/12^b	NA	HVRII	Kirches et al. 1999

^a Number of tumors with mutations/number of tumors
^b 2 of the 12 astrocytomas were compared to adjacent brain, the remaining 10 were aligned to Anderson et al. 1981 for mutation analysis
^c Number of mutations causing amino acid substitutions/total number of mutations found in all tumors
^d NA, not applicable because in hypervariable region of the D-loop (HVR)

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