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Table 3 IC50values obtained after 24 h exposure to TPL followed by 1 h exposure to DOX and 72 h incubation in drug free medium (mean ± s.e.m. of 4–6 independent experiments).

From: Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin

  DOX + TPL (IC25) + TPL (IC50) C.I.a
HCT116 0.38 ± 0.03 0.102 ± 0.04 0.053 ± 0.003 0.4–0.6
HT29 2.20 ± 0.11 1.06 ± 0.12 0.49 ± 0.015 0.6–0.8
HCT116 E6 0.77 ± 0.06 0.54 ± 0.6 0.24 ± 0.07 0.6–0.8
HCT116 p21-/- 5.457 ± 0.16 4.98 ± 0.15 2.549 ± 0.21 0.8–1.1
  1. a Combination index (C.I.) ≈ 1.0: additivity; C.I.<1.0: synergy; C.I.>1.0: antagonism