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Table 3 IC50values obtained after 24 h exposure to TPL followed by 1 h exposure to DOX and 72 h incubation in drug free medium (mean ± s.e.m. of 4–6 independent experiments).

From: Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin

 

DOX

+ TPL (IC25)

+ TPL (IC50)

C.I.a

HCT116

0.38 ± 0.03

0.102 ± 0.04

0.053 ± 0.003

0.4–0.6

HT29

2.20 ± 0.11

1.06 ± 0.12

0.49 ± 0.015

0.6–0.8

HCT116 E6

0.77 ± 0.06

0.54 ± 0.6

0.24 ± 0.07

0.6–0.8

HCT116 p21-/-

5.457 ± 0.16

4.98 ± 0.15

2.549 ± 0.21

0.8–1.1

  1. a Combination index (C.I.) ≈ 1.0: additivity; C.I.<1.0: synergy; C.I.>1.0: antagonism
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BMC Cancer

ISSN: 1471-2407

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