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Table 1 IC50values obtained after 1 h exposure to DOX followed by 72 h incubation in drug free medium (mean ± s.e.m. of 4–6 independent experiments).

From: Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin

cell lines

IC50 (μM)

R.I.a

HCT116

0.38 ± 0.03

1.0

HT29

2.37 ± 0.13 *

6.24

HCT116 E6

0.732 ± 0.06 *

1.93

HCT116 p21-/-

4.98 ± 0.32 *

13.10

  1. *p < 0.05 vs HCT116
  2. aThe resistance index (R.I.) was calculated as the ratio between the IC50 values obtained for each cell line and that of HCT116 cells
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BMC Cancer

ISSN: 1471-2407

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