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Table 1 IC50values obtained after 1 h exposure to DOX followed by 72 h incubation in drug free medium (mean ± s.e.m. of 4–6 independent experiments).

From: Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin

cell lines IC50 (μM) R.I.a
HCT116 0.38 ± 0.03 1.0
HT29 2.37 ± 0.13 * 6.24
HCT116 E6 0.732 ± 0.06 * 1.93
HCT116 p21-/- 4.98 ± 0.32 * 13.10
  1. *p < 0.05 vs HCT116
  2. aThe resistance index (R.I.) was calculated as the ratio between the IC50 values obtained for each cell line and that of HCT116 cells