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Figure 2 | BMC Cancer

Figure 2

From: Wnt1 is epistatic to Id2 in inducing mammary hyperplasia, ductal side-branching, and tumors in the mouse

Figure 2

Carmine stained mammary gland whole mounts were made from virgin females. Top row, left to right: normal mammary gland development was observed in wild type (13 weeks), Id2 +/- (26 weeks), and Id2-/- (26 weeks) animals. Bottom row, left to right: Wnt1 induced hyperplasia and side branching were forced when the MMTV-Wnt1 transgene was present in wild type, Id2+/-, and Id2 -/- animals (all 19 weeks). Branching patterns are representative of a consistent phenotype observed in all mice and in both tumor-free glands and in glandular tissue associated with tumors in the MMTV-Wnt1 mice.

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