| Rare allele frequency | To age 50 | To age 70 | ||||||
---|---|---|---|---|---|---|---|---|---|
Polymorphism* | Â | N** | RR | 95% CI | p-value | N** | RR | 95% CI | p-value |
Base excision repair genes | Â | Â | Â | Â | Â | Â | Â | Â | Â |
XRCC1 R194W | 0.06 | Â | Â | Â | Â | Â | Â | Â | Â |
   RR |  | 51 | 1.0 | --- |  | 125 | 1.0 | --- |  |
   RW or WW |  | 6 | 1.4 | 0.4–4.2 | 0.408 | 22 | 2.3 | 1.3–3.8 | 0.004 |
XRCC1 R280H | 0.03 | Â | Â | Â | Â | Â | Â | Â | Â |
   RR |  | 52 | 1.0 | --- |  | 134 | 1.0 | --- |  |
   RH or HH |  | 5 | 0.7 | 0.0–2.4 | 0.736 | 13 | 1.2 | 0.5–2.5 | 0.522 |
XRCC1 R399Q | 0.37 | Â | Â | Â | Â | Â | Â | Â | Â |
   RR |  | 21 | 1.0 | --- |  | 59 | 1.0 | --- |  |
   RQ |  | 22 | 0.7 | 0.1–2.0 | 0.444 | 64 | 1.1 | 0.4–1.6 | 0.636 |
   QQ |  | 14 | 3.4 | 1.3–9.3 | 0.014 | 24 | 1.9 | 1.1–3.9 | 0.010 |
APEX Q51H | 0.04 | Â | Â | Â | Â | Â | Â | Â | Â |
   QQ |  | 49 | 1.0 | --- |  | 134 | 1.0 | --- |  |
   QH or HH |  | 7 | 3.0 | 0.5–6.7 | 0.216 | 12 | 1.7 | 0.7–3.1 | 0.236 |
APEX D148E | 0.49 | Â | Â | Â | Â | Â | Â | Â | Â |
   DD |  | 20 | 1.0 | --- |  | 49 | 1.0 | --- |  |
   DE |  | 27 | 0.2 | 0.1–0.8 | 0.028 | 65 | 0.2 | 0.1–0.5 | <0.001 |
   EE |  | 9 | 0.8 | 0.2–1.9 | 0.546 | 32 | 1.0 | 0.6–1.7 | 0.860 |
POLD1 R119H | 0.06 | Â | Â | Â | Â | Â | Â | Â | Â |
   RR |  | 44 | 1.0 | --- |  | 123 | 1.0 | --- |  |
   RH or HH |  | 13 | 2.5 | 0.8–5.0 | 0.106 | 24 | 1.8 | 1.0–2.9 | 0.058 |
BRCA1 interacting proteins | Â | Â | Â | Â | Â | Â | Â | Â | Â |
BRCA2 N289H | 0.03 | Â | Â | Â | Â | Â | Â | Â | Â |
   MM |  | 57 | 1.0 | --- |  | 141 | 1.0 | --- |  |
   NH or HH |  | 0 | 0 | --- | ---- | 6 | 1.6 | 0.5–2.9 | 0.370 |
BRCA2 N372H | 0.32 | Â | Â | Â | Â | Â | Â | Â | Â |
   NN |  | 30 | 1.0 | --- |  | 89 | 1.0 | --- |  |
   NH |  | 23 | 0.4 | 0.1–1.3 | 0.140 | 42 | 0.2 | 0.1–0.5 | <0.001 |
   HH |  | 4 | 1.5 | 0.4–4.4 | 0.322 | 16 | 1.3 | 0.8–2.4 | 0.232 |
BRCA2 T1915M | 0.05 | Â | Â | Â | Â | Â | Â | Â | Â |
   TT |  | 53 | 1.0 | --- |  | 139 | 1.0 | --- |  |
   TM or MM |  | 4 | 1.7 | 0.0–4.0 | 0.664 | 8 | 2.1 | 0.6–3.6 | 0.215 |
BRIP1 -64 G>A | 0.46 | Â | Â | Â | Â | Â | Â | Â | Â |
   GG |  | 17 | 1.0 | --- |  | 42 | 1.0 | --- |  |
   GA |  | 24 | 0.4 | 0.1–1.2 | 0.126 | 70 | 0.7 | 0.2–1.2 | 0.112 |
   AA |  | 16 | 1.5 | 0.5–4.3 | 0.424 | 35 | 1.6 | 0.8–2.8 | 0.218 |
BRIP1 P919S | 0.43 | Â | Â | Â | Â | Â | Â | Â | Â |
   PP |  | 10 | 1.0 | --- |  | 52 | 1.0 | --- |  |
   PS |  | 34 | 4.5 | 0.8–12.2 | 0.096 | 69 | 0.6 | 0.3–1.2 | 0.134 |
   SS |  | 12 | 6.9 | 1.6–29.3 | 0.018 | 25 | 1.3 | 0.8–2.8 | 0.220 |
ZBRK1 L66P | 0.15 | Â | Â | Â | Â | Â | Â | Â | Â |
   LL |  | 43 | 1.0 | --- |  | 108 | 1.0 | --- |  |
   LP or PP |  | 14 | 0.9 | 0.3–2.0 | 0.712 | 38 | 1.2 | 0.7–1.9 | 0.304 |
ZBRK1 S472P | 0.12 | Â | Â | Â | Â | Â | Â | Â | Â |
   SS |  | 55 | 1.0 | --- |  | 137 | 1.0 | --- |  |
   SP or PP |  | 2 | 0.8 | 0.0–2.2 | 0.614 | 10 | 1.6 | 0.6–2.9 | 0.312 |
ZBRK1 R501S | 0.12 | Â | Â | Â | Â | Â | Â | Â | Â |
   RR |  | 46 | 1.0 | --- |  | 116 | 1.0 | --- |  |
   RS or SS |  | 11 | 0.8 | 0.2–1.8 | 0.534 | 31 | 1.2 | 0.7–2.1 | 0.434 |
ZBRK1 1845 C>T | 0.06 | Â | Â | Â | Â | Â | Â | Â | Â |
   CC |  | 45 | 1.0 | --- |  | 121 | 1.0 | --- |  |
   CT or TT |  | 12 | 2.2 | 0.5–4.3 | 0.218 | 25 | 1.6 | 0.8–2.8 | 0.162 |
Growth factor genes | Â | Â | Â | Â | Â | Â | Â | Â | Â |
TGFß1 L10P | 0.38 |  |  |  |  |  |  |  |  |
   LL |  | 25 | 1.0 | --- |  | 54 | 1.0 | --- |  |
   LP or PP |  | 31 | 0.5 | 0.2–1.2 | 0.148 | 92 | 0.8 | 0.5–1.5 | 0.536 |
TGFß1 P25R | 0.10 |  |  |  |  |  |  |  |  |
   PP |  | 48 | 1.0 | --- |  | 126 | 1.0 | --- |  |
   PR or RR |  | 8 | 1.0 | 0.1–3.1 | 0.952 | 20 | 1.2 | 0.6–2.1 | 0.554 |
TGFß1 T263I | 0.04 |  |  |  |  |  |  |  |  |
   TT |  | 54 | 1.0 | --- |  | 138 | 1.0 | --- |  |
   TI or II |  | 3 | 2.1 | 0.0–4.9 | 0.492 | 9 | 1.7 | 0.6–3.1 | 0.312 |
IGFBP3 -202 A>C | 0.53*** | Â | Â | Â | Â | Â | Â | Â | Â |
   AA |  | 11 | 1.0 | --- |  | 36 | 1.0 | --- |  |
   AC or CC |  | 45 | 1.0 | 0.3–3.5 | 0.848 | 110 | 0.7 | 0.4–1.3 | 0.228 |