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Figure 1 | BMC Cancer

Figure 1

From: BAG-1 haplo-insufficiency impairs lung tumorigenesis

Figure 1

BAG-1 haplo-insufficiency delays C-Raf driven adenoma growth. (a) Adenoma initiation in SP-C C-Raf BxB mice (BAG-1+/+) and their Bag-1 haplo-insufficient littermates (BAG-1+/-) at 1, 2 and 4 months of age. Adenoma foci values represent mean ± s.e. from at least 4 mice of each genotype analyzed in a blinded fashion by two independent readers. (b) Adenoma area in the lungs of 4 months old mice. Each value represents mean ± s.e. from at least 4 mice of each genotype analyzed in a blinded fashion. (c-d) Examples of hematoxylin-eosin stained sections of lungs from SP-C C-Raf BxB transgenic mice wildtype for BAG-1 in comparison to a BAG-1 heterozygous littermate. Scale bar, 200 μm.

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