Drug/Combination | N | AUC | IC90 | IC50 | IndexSUM | % showing decrease in IndexSUM when in combination with gefitinib |
---|---|---|---|---|---|---|
Gefitinib | 86 | 3943 (40–13212) | 646 (243–12614) | 399 (4–7008) | 570 (187–818) | - |
Cisplatin | 6 | 7937 (4244–9804) | 294 (208–557) | 132 (84–309) | 434 (382–497) | - |
Cisplatin + gefitinib | 6 | 9006 (1731–12057) | 225 (159–585) | 107 (58–325) | 486 (351–588) | 33% (2/6) |
Gemcitabine | 2 | 7127 (498–13756) | 764 (206–1321) | 382 (30–734) | 452 (288–616) | - |
Gemcitabine + gefitinib | 2 | 12605 (9835–15374) | 211 (201–220) | 52 (17–86) | 315 (207–422) | 100% (2/2) |
Oxaliplatin | 10 | 3488 (874–8884) | 833 (317–2267) | 463 (129–1259) | 559 (379–681) | - |
Oxaliplatin + gefitinib | 10 | 5602 (547–12140) | 390 (194–775) | 217 (60–431) | 447 (310–605) | 90% (9/10) |
Treosulfan | 34 | 13764 (4351–18390) | 146 (35–616) | 53 (4–342) | 353 (65–726) | - |
Treosulfan + gefitinib | 34 | 13656 (4251–18658) | 153 (31–19892) | 60 (4–11051) | 338 (58–897) | 56% (19/34) |
Treosulfan + gemcitabine | 24 | 17576 (8107–19164) | 57 (6–200) | 13 (3–110) | 155 (21–456) | - |
Treosulfan + gemcitabine+ gefitinib | 24 | 17281 (11402–19119) | 48 (9–206) | 9 (4–70) | 146 (25–572) | 54% (13/24) |