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Table 1 VG-IgG2κ and VG-IgM epitope mapping

From: Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers

  

Tracer MAb

Gold epitope

Inhibitor Mab

VG-IgG2κ

VG-IgM

X4

1

F6

1a

2

<1

2

35A7

<1

9

3

3

B17

31

<1

13

4

CE25

99

95

83

4

X4

98

89

68

5

192

3

11

<1

  1. aResults are expressed as a percentage of inhibition of the binding of radiolabeled tracer MAbs by an excess of the reference MAbs directed against the five Gold CEA epitopes.