Figure 6

CD155 mediates motility of GBM cells. FALI of CD155 using multiple mAbs resulted in a significant inhibition of U87MG GBM cell transwell migration towards a serum chemoattractant (no Ab 3 ± 3%; β1-int 47 ± 3%; 1A2 (control, surface binding scFv) 3 ± 2%; CD155: D171 17 ± 2%; pv404 22 ± 2%; 5D11 16 ± 3%; IDS 17 ± 2%; CD155pool21 ± 4%; * indicates p < 0.01, t-test). FALI with CD155 mAb pools did not yield greater inhibition, suggesting maximal inactivation or a common binding site.