Classification between normal and tumor tissues based on the pair-wise gene expression ratio

BMC Cancer

Table 6 Colon cancer: the top 10 genes and pair-wise gene expression ratio used to discriminate the colon cancer tissue. This table is ranked with decreasing classification efficiency. The threshold values T _i for normal tissues are also provided together with classification efficiency. The list of top 25 genes can be downloaded from http://web.hku.hk/~daniely/microarray.

Colon Cancer-Original data							Colon Cancer-Transformed data
Rank	No. on array	gene accession number	gene info	Threshold for normal tissue type, T _j	discriminating efficiency*/%	Ref	Rank	gene number on array	Threshold for normal tissue type, T _i	discriminating efficiency*/%	Ref
1	#1659	M26383	Human monocyte-derived neutrophil-activating protein (MONAP) mRNA, complete cds.	<62.7375	87.1%	[12,13]	1	#1537/#1831	<0.75512	93.6%	[27,28]
2	#753	M76378	Human cysteine-rich protein (CRP) gene, exons 5 and 6.	>749.4075	83.9%	[26]	2	#1831/#1537	>1.3243	93.6%	[27,28]
3	#613	X12671	Human gene for heterogeneous nuclear ribonucleoprotein (hnRNP) core protein A1.	<233.4162	82.3%	[33]	3	#1827/#481	<0.074449	91.9%	[14,15,39]
4	#569	T51571	P24480 CALGIZZARIN. SERINE/THREONINE-PROTEIN	<309.3037	77.4%	[34]	4	#1537/#1623	<1.0533	91.9%	[27,40]
5	#1103	R97912	KINASE IPL1 (Saccharomyces cerevisiae)	<70.2738	75.8%	[35]	5	#1831/#1759	>1.4003	91.9%	[28]
6	#1759	J05032	Human aspartyl-tRNA synthetase alpha-2 subunit mRNA, complete cds.	<41.92	75.8%	[36]	6	#1623/#1537	>0.94939	91.9%	[27,40]
7	#241	M63391	Human desmin gene, complete cds.	>2787.0425	75.8%	[17]	7	#365/#1760	>3.3867	91.9%	[41,42]
8	#818	R75843	TRANSLATIONAL INITIATION FACTOR 2 GAMMA SUBUNIT (Homo sapiens)	<152.5662	74.2%	[37]	8	#1759/#1831	<0.71414	91.9%	[28]
9	#1960	T57468	FIBRILLARIN (HUMAN).	<42.0225	74.2%	[38]	9	#1760/#365	<0.29528	91.9%
10	#1281	H23544	GTP-BINDING NUCLEAR PROTEIN RNA (Homo sapiens)	<103.2488	74.2%	[20]	10	#481/#1827	>13.432	91.9%	[14,15,39]

ISSN: 1471-2407