HFE C282Y and H63D in adults with malignancies in a community medical oncology practice

BMC Cancer

Table 2 HFE C282Y and H63D Allele Frequencies in 54 Adults with 58 Carcinomas.*

Histology, Primary Site of Malignancy (no. of cases) †	C282Y	Odds Ratio (value of p)	H63D	Odds Ratio (value of p)
Adenocarcinoma of breast (18)	0.0278	0.3 (0.3269)	0.2500	2.0 (0.1386)
Adenocarcinoma of colon or rectum (12)	0.0417	0.4 (0.6445)	0.1250	0.8 (0.9725)
Non-small cell carcinoma of lung (7)	0.1429	1.7 (0.7360)	0	-(0.7631)
Adenocarcinoma of prostate (4)	0.2500	3.4 (0.3230)	0.2500	2.0 (0.6602)
Adenocarcinoma of undetermined primary site (4)	0	-(0.7841)	0	-(0.7267)
Hepatocellular carcinoma (4)	0.1250	1.5 (0.7841)	0.1250	0.8 (0.7267)
Adenocarcinoma of kidney (3)	0	-(0.8695)	0	-(0.6668)
Adenocarcinoma of stomach (3)	0	-(0.8695)	0.1667	1.2 (0.6668)
Miscellaneous (3)	0.3333	‡	0.1667	‡

* Frequencies of C282Y and H63D were compared to those in 318 controls; odds ratios were not calculated in categories in which C282Y or H63D alleles were not detected. † All cases of adenocarcinoma of the breast occurred in women. Two women had both adenocarcinoma of the breast and B-chronic lymphocytic leukemia; two other women had both adenocarcinoma of the breast and adenocarcinoma of the colon or rectum. One man had both B-chronic lymphocytic leukemia and non-small cell carcinoma of the lung, one man had non-small cell carcinoma of the lung and adenocarcinoma of the stomach, and a third man had B-cell non-Hodgkin lymphoma, adenocarcinoma of the rectum, and adenocarcinoma of the kidney. None of the cases of hepatocellular carcinoma were associated with iron overload. Miscellaneous category includes one case each of primary peritoneal adenocarcinoma, adenocarcinoma of the pancreas, and primary cutaneous melanoma. ‡ OR and values of p are not reported for this subgroup because it is composed of a heterogeneous group of malignancies.

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