HFE C282Y and H63D in adults with malignancies in a community medical oncology practice

BMC Cancer

Table 1 HFE C282Y and H63D Allele Frequencies in 50 Adults with 52 Hematologic Malignancies.*

Classification of Malignancy (no. of cases) †	C282Y	Odds Ratio (value of p)	H63D	Odds Ratio (value of p)
B-cell non-Hodgkin lymphoma (12)	0.1667	2.0 (0.3461)	0.0833	0.5 (0.5848)
B-cell chronic lymphocytic leukemia (9)	0.0555	0.6 (0.9355)	0.0555	0.4 (0.4957)
Plasma cell myeloma (6)	0.0833	0.9 (0.7398)	0	-(0.8538)
Myelodysplasia (13)	0.0385	0.4 (0.6331)	0.1923	1.4 (0.6582)
Myeloproliferative disorders (7)	0.2143	2.8 (0.2597)	0.2857	2.4 (0.2755)
Acute Leukemia (5)	0.1000	1.1 (0.6579)	0	-(0.9565)

* Frequencies of C282Y and H63D were compared to those in 318 controls; odds ratios were not calculated in categories in which C282Y or H63D alleles were not detected. † B-cell non-Hodgkin lymphoma included high, intermediate, and low histologic grades in two, four, and six cases, respectively. B-cell chronic lymphocytic leukemia included one case of hairy cell leukemia. Plasma cell myeloma was IgG-specific in five cases and IgA-specific in one case. Myelodysplasia included eleven cases of refractory anemia (nine with ringed sideroblasts), and two cases of refractory anemia with excess blasts in transformation. Myeloproliferative disorders included six cases of polycythemia rubra vera and one case of Ph-positive chronic myelogenous leukemia. Among the six patients who had polycythemia rubra vera, two were heterozygous for C282Y, one was a compound C282Y/H63D heterozygote, one was homozygous for H63D, and two did not have C282Y or H63D. The one patient with Ph-positive chronic myelogenous leukemia was heterozygous for H63D. There were three cases of acute non-lymphoblastic leukemia and two cases of acute lymphoblastic leukemia (1 T-cell, 1 B-cell). One man had both B-chronic lymphocytic leukemia and plasma cell myeloma, one man had B-chronic lymphocytic leukemia and non-small cell carcinoma of the lung, and one man had B-cell non-Hodgkin lymphoma, adenocarcinoma of the rectum, and adenocarcinoma of the kidney. One woman had polycythemia rubra vera and non-Hodgkin lymphoma.

ISSN: 1471-2407