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Table 3 Anti-proliferative effects of tipifarnib for AML cell lines.

From: Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia

Cell line

IC50 (nM)†

ras status

AML-193

134

H-ras(12), N-ras(13)

HL-60

24

H-ras(12)

THP-1

19

K-ras(13) N-ras(12, 61)

U-937

44

Wild-type

  1. † The IC50 was calculated from two independent experiments. The mean value is shown.