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Table 3 Anti-proliferative effects of tipifarnib for AML cell lines.

From: Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia

Cell line IC50 (nM)† ras status
AML-193 134 H-ras(12), N-ras(13)
HL-60 24 H-ras(12)
THP-1 19 K-ras(13) N-ras(12, 61)
U-937 44 Wild-type
  1. † The IC50 was calculated from two independent experiments. The mean value is shown.