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Table 3 (A) 11q23 LOH data of NB patients (35 patients form the Molecular Oncology Unit (Lyon, France) (F-samples) and 32 patients from the Ghent University Hospital (Ghent, Belgium) (G-samples)). Based on the allelic imbalance factor (AIF) of 6 markers (4 on 11q23 and 2 on 11p) normal 11q23 status was distinguished from unbalanced 11q LOH and loss of both 11q and 11p (here indicated as whole chromosome loss) (- = no data available) and (B) 11q23 status in NB cell lines based on FISH, LOH, karyotypes, CGH and/or M-FISH

From: No evidence for involvement of SDHD in neuroblastoma pathogenesis

A
NB tumour case 11q23 LOH status MYCNampl 1p del stage NB tumour case 11q23 LOH status MYCNampl 1p del stage
F1 normal no no 3 G1 normal no no 4
F2 normal no no 3 G2 whole chr11 loss no no 4
F3 normal no no 3 G3 normal no no 1
F4 normal no no 4 G4 normal no no 1
F5 whole chr11 loss no no 4 G5 normal no no 2
F6 unb [11q]LOH no no 4 G6 normal - no 3
F7 normal no no 4 G7 normal - - 4
F8 normal no no 3 G8 normal no no 1
F9 normal no no 4 G9 whole chr11 loss no no 4
F10 whole chr11 loss no no 3 G10 normal no no 4
F11 normal no no 4 G11 normal no no 1
F12 normal no no 4 G12 normal no no 4
F13 normal no no 3 G13 normal no yes 1
F14 whole chr11 loss no no 3 G14 whole chr11 loss no no 3
F15 whole chr11 loss no yes 4 G15 normal no no 3
F16 normal no no 3 G16 normal - no 4
F17 unb [11q]LOH no no 4 G17 normal no no 3
F18 unb [11q]LOH no yes 4 G18 normal no yes 1
F19 normal no no 4 G19 normal no no 4S
F20 normal no no 3 G20 normal yes yes 3
F21 unb [11q]LOH no no 4 G21 unb [11q]LOH no no 3
F22 whole chr11 loss no no 3 G22 unb [11q]LOH yes yes 4
F23 normal no no 3 G23 normal no no 4
F24 normal no no 3 G24 normal yes yes 4
F25 whole chr11 loss no no 3 G25 normal no no 4
F26 unb [11q]LOH no no 4 G26 normal no yes 4
F27 whole chr11 loss no no 3 G27 normal no no 3
F28 normal no no 3 G28 normal - no 2
F29 unb [11q]LOH no no 4 G29 normal no no 3
F30 normal no yes 4 G30 normal no no 1
F31 normal no no 4 G31 normal - no 3
F32 normal no no 4 G32 normal no no 4S
F33 whole chr11 loss no no 3      
F34 normal no yes 4      
F35 unb [11q]LOH no no 4      
B
NB cell line 11q23 status MYCN ampl 1p del       
CHP-134 normal yes yes       
CHP-901 normal yes yes       
CHP-902R normal yes yes       
CLB-GA deletion no no       
GI-M-EN deletion no yes       
IMR-32 deletion yes yes       
LA-N-1 normal yes yes       
LA-N-2 normal yes no       
LA-N-5 normal yes yes       
LA-N-6 deletion no yes       
N206 normal yes yes       
NBL-S deletion no no       
NGP deletion yes yes       
NLF normal yes yes       
NMB normal yes yes       
SJNB-12 normal no yes       
SJNB-1 normal no yes       
SJNB-10 normal yes yes       
SJNB-6 normal yes yes       
SJNB-8 normal yes yes       
SK-N-AS deletion no yes       
SK-N-BE normal yes yes       
SK-N-FI normal no no       
SK-N-SH normal no no       
SMS-KAN normal yes yes       
SMS-KCNR normal yes yes       
STA-NB-10 normal yes yes       
STA-NB-3 normal yes yes       
STA-NB-8 normal yes yes       
TR-14 normal yes yes       
UHG-NP normal yes yes