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Figure 6 | BMC Cancer

Figure 6

From: Opposite role of Bax and BCL-2 in the anti-tumoral responses of the immune system

Figure 6

A. Vaccination protocol for the anti-tumoral immune response induced by huBax A15A5 cells, apoptotic bodies or oncolysates to pCMV or huBcl-2 A15A5 cells in rats. Rats were pretreated with PBS, oncolysate (OL) or apoptotic bodies (AB) from pCMV A15A5 cells or huBax A15A5 cells, 15, 10 and 5 days before being challenged with pCMV or huBcl-2 A15A5 cells. B. Comparison of tumor growth of pCMV A15A5 cells injected into syngenic BDIX rats. Four groups of 6 BDIX rats were treated as in A then on day 0 were challenged with 105 pCMV A15A5 cells injected sc and tumoral growth was followed for an 60 days. Data presented are illustrative of 3 independent experiments. C. Comparison of tumor growth of huBcl-2 A15A5 cells injected into syngenic BDIX rats. Four groups of 6 BDIX rats were treated as in A then on day 0 were challenged with 105 huBcl-2 A15A5 cells injected sc and tumoral growth was followed for an 60 days. Data presented are illustrative of 3 independent experiments.

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