TY - JOUR AU - Teufel, Andreas AU - Steinmann, Silke AU - Siebler, Jürgen AU - Zanke, Christiane AU - Hohl, Herbert AU - Adami, Bernd AU - Schroeder, M. AU - Klein, O. AU - Höhler, Thomas AU - Galle, Peter R. AU - Heike, Michael AU - Moehler, Markus PY - 2004 DA - 2004/07/20 TI - Irinotecan plus folinic acid/continuous 5-fluorouracil as simplified bimonthly FOLFIRI regimen for first-line therapy of metastatic colorectal cancer JO - BMC Cancer SP - 38 VL - 4 IS - 1 AB - Combination therapy of irinotecan, folinic acid (FA) and 5-fluorouracil (5-FU) has been proven to be highly effective for the treatment of metastatic colorectal cancer. However, in light of safety and efficacy concerns, the best combination regimen for first-line therapy still needs to be defined. The current study reports on the bimonthly FOLFIRI protocol consisting of irinotecan with continuous FA/5-FU in five German outpatient clinics, with emphasis on the safety and efficiency, quality of life, management of delayed diarrhea, and secondary resection of regressive liver metastases. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-4-38 DO - 10.1186/1471-2407-4-38 ID - Teufel2004 ER -