The influence of tumor size and environment on gene expression in commonly used human tumor lines

Gieseg, Michael A; Man, Michael Z; Gorski, Nicholas A; Madore, Steven J; Kaldjian, Eric P; Leopold, Wilbur R

doi:10.1186/1471-2407-4-35

BMC Cancer

Table 1 Genes with high expression in HCT-116 tumors grown in C.B-17 SCID mice

From: The influence of tumor size and environment on gene expression in commonly used human tumor lines

Function	Affymetrix Probe Set ID	ANOVA p-value	BH p-value¹	Log2 FC²	Gene Symbol	LocusLink ID	Sequence Probe Derived From	Gene Title
Translation/RNA binding/RNA splicing
	34733_at	0.00029	0.046	0.5	SF3A1	10291	X85237	splicing factor 3a, subunit 1, 120 kDa
	34829_at	0.00020	0.046	0.4	DKC1	1736	U59151	dyskeratosis congenita 1, dyskerin
	35174_i_at	0.00020	0.046	0.4	EEF1A2	1917	X70940	eukaryotic translation elongation factor 1 alpha 2
	37462_i_at	0.00013	0.042	0.5	SF3A2	8175	L21990	splicing factor 3a, subunit 2, 66 kDa
	39047_at	0.00007	0.030	0.5	SART3	9733	AB020880	squamous cell carcinoma antigen recognised by T cells 3
	40490_at	0.00041	0.049	0.7	DDX21	9188	U41387	DEAD/H box polypeptide 21
Signal transduction
	33887_at	0.00029	0.046	0.5	HGS	9146	D84064	hepatocyte growth factor-regulated tyrosine kinase substrate
	38019_at	0.00002	0.028	1.0	CSNK1E	1454	L37043	casein kinase 1, epsilon
	38779_r_at	0.00039	0.048	0.8	HDGF	3068	D16431	hepatoma-derived growth factor
	40864_at	0.00029	0.046	0.4	RAC1	5879	D25274	ras-related C3 botulinum toxin substrate
Small Molecule transport
	32186_at	0.00023	0.046	0.7	SLC7A5	8140	M80244	solute carrier family 7, member 5
	36557_at	0.00003	0.028	0.9	CACNB1	782	M92303	calcium channel, voltage-dependent, beta 1 subunit
	38029_at	0.00031	0.046	0.4	SLC3A2	6520	J02939	solute carrier family, member 2
Protein Complex Assembly
	31842_at	0.00044	0.050	0.5	BCS1L	617	AF038195	BCS1-like (yeast)
	32575_at	0.00019	0.046	0.4	NAP1L4	4676	U77456	nucleosome assembly protein 1-like 4
Protein transport and folding
	36945_at	0.00036	0.047	0.5	C12orf8	10961	X94910	chromosome 12 open reading frame 8
	40756_at	0.00017	0.046	0.4	NPM3	10360	AF081280	nucleophosmin/nucleoplasmin, 3
Unknown or other functions
	31670_s_at	0.00023	0.046	0.3	SRP72	6731	U81554	signal recognition particle 72 kDa
	34279_at	0.00005	0.030	2.0	FLJ20719	55672	AL050141	hypothetical protein FLJ20719
	36192_at	0.00003	0.028	0.7	KIAA0193	9805	D83777	KIAA0193 gene product
	36209_at	0.00003	0.028	0.8	BRD2	6046	S78771	bromodomain containing 2
	36210_g_at	0.00035	0.047	1.0	BRD2	6046	S78771	bromodomain containing 2
	36668_at	0.00035	0.047	0.4	DIA1	1727	M28713	diaphorase (NADH)
	37907_at	0.00006	0.030	0.4	F8A	8263	M34677	coagulation factor VIII-associated
	38885_at	0.00000	0.007	1.0	DNA2L	1763	D42046	DNA2 DNA replication helicase 2-like
	39436_at	0.00010	0.039	1.5	BNIP3L	665	AF079221	BCL2/adenovirus E1B 19 kDa interacting protein 3-like
	39758_f_at	0.00030	0.046	0.4	LAMP1	3916	J04182	lysosomal-associated membrane protein 1
	39832_at	0.00007	0.030	0.5	ARS2	51593	AL096723	arsenate resistance protein ARS2
	40589_at	0.00041	0.049	0.9	SNTB2	6645	U40572	syntrophin, beta 2
	40604_at	0.00012	0.040	1.1	DYRK2	8445	Y13493	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
	41062_at	0.00028	0.046	0.7	NSPC1	84759	AA037278	likely ortholog of mouse nervous system polycomb 1
	982_at	0.00011	0.039	0.4	MCM5	4174	X74795	MCM5 minichromosome maintenance deficient 5, cell division cycle 46

¹p-value resulting from Benjamini and Hochberg procedure ² log2 fold change calculated by dividing expression level from C.B-17 SCID sample by expression level of Nu/Nu sample

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ISSN: 1471-2407

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