Association of HLA Class I and Class II genes with bcr-abl transcripts in leukemia patients with t(9;22) (q34;q11)

Table 2 b2a2 association with HLA Class I and II in leukemia patients and healthy donors with statistical analysis

HLA	ALLELE	LEUKEMIA PATIENTS*	HEALTHY DONORS*	RELATIVE RISK	CHI-SQUARE	BINDING SCORE
A	01	32	78	1.76	6.35	3
A	02	50	275	0.63	6.66	6
A	23	9	13	2.85	6.12
A	66	5	4	5.09	7.15
A	68	5	107	0.16	19.20	6
B	14	9	99	0.32	10.88	7
B	15	6	60	0.37	5.56
B	37	3	2	5.94	4.87
B	38	7	11	2.55	3.89
B	40	3	64	0.17	11.22
B	42	3	1	11.90	7.40
B	45	5	5	3.99	5.48
B	49	3	2	5.94	4.87
B	53	9	3	12.26	22.38	9
B	56	4	2	7.97	7.99
B	62	6	0	45060000.00	23.62	0
DQB1	0201	23	36	1.89	5.29
DQB1	0303	4	30	0.36	3.90
DQB1	0402	10	9	3.22	6.95
DQB1	0603	8	50	0.42	5.11
DQB1	0609	4	0	21480000.00	11.25
DRB1	0301	23	36	1.89	5.29
DRB1	0302	3	0	16110000.00	8.43
DRB1	0901	4	1	11.40	7.47
DRB1	1001	5	2	7.15	7.41
DRB1	1101	10	53	0.50	3.89
DRB1	1201	3	0	16110000.00	8.43
DRB1	1202	2	0	10740000.00	5.61
DRB1	1503	5	1	14.33	10.13

*Figures shown are the gene frequencies. For a significance level of = 0.05 needed to reject the null hypothesis, the chi square statistic must be > 3.84

ISSN: 1471-2407