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Table 3 RT-PCR. Level of expression of Core I in tumours and corresponding normal tissues.

From: Core I gene is overexpressed in Hürthle and non-Hürthle cell microfollicular adenomas and follicular carcinomas of the thyroid

Case Age/Sex

Diagnosis

Tumour Core I/Actin %a

Normal Core I/Actin %a

Level of Expression *

MIB-1b %

1 64/F

HFC

46.2 ± 0.3

21.0 ± 0.5

2.2

1.1

2 33/M

HFC

52.1 ± 1.8

22.8 ± 1.3

2.3

1.0

3 47/M

HFC

52.1 ± 2.2

24.8 ± 1.1

2.1

0.9

4 59/F

HFC

54.6 ± 0.8

22.2 ± 1.0

2.5

0.5

5 55/F

HFC

47.7 ± 1.2

22.7 ± 0.8

2.1

0.9

6 24/F

HFC

50.2 ± 0.9

23.9 ± 1.2

2.1

0.9

7 55/F

HFC

41.5 ± 1.2

21.9 ± 1.4

1.9

0.8

8 64/F

FC

46.4 ± 2.8

25.8 ± 1.6

1.8

1.1

9 46/F

FC

48.9 ± 2.1

23.4 ± 0.8

2.1

1.6

10 71/F

HmFA

47.2 ± 2.7

22.6 ± 1.8

2.1

1.1

11 24/F

mFA

47.3 ± 3.3

26.4 ± 0.8

1.8

0.3

12 69/F

mFA

45.1 ± 2.3

27.6 ± 1.3

1.6

0.0

13 57/F

mFA

42.8 ± 1.8

22.5 ± 0.9

1.9

0.5

14 27/F

mFA

48.8 ± 2.2

23.2 ± 1.1

2.1

0.9

15 53/F

mFA

49.0 ± 2.1

22.7 ± 0.8

2.2

1.1

16 65/F

mFA

52.4 ± 2.4

24.9 ± 0.9

2.1

0.7

17 31/F

mMFA

35.8 ± 2.3

27.6 ± 1.3

1.3

0.1

18 52/F

PC

30.0 ± 0.2

27.3 ± 0.1

1.1

0.7

19 46/F

PC

24.2 ± 0.5

26.9 ± 0.1

0.9

1.1

20 52/F

PC

39.8 ± 2.6

37.3 ± 0.0

1.1

0.7

21 47/F

PC

26.7 ± 3.4

33.5 ± 3.7

0.8

3.0

22 52/F

PC

16.7 ± 0.6

24.6 ± 0.4

0.7

0.7

23 68/F

PC

24.1 ± 0.8

24.0 ± 0.6

1.0

0.8

24 60/F

HPC

20.9 ± 1.2

23.2 ± 0.9

0.9

1.5

25 62/F

HPC

16.4 ± 1.2

22.2 ± 0.8

0.7

0.4

26 11/M

HPC

27.4 ± 0.9

22.8 ± 2.1

1.2

1.1

27 30/F

HMFA

19.9 ± 0.1

28.6 ± 2.3

0.7

0.4

28 42/F

MFA

18.5 ± 0.1

24.8 ± 0.1

0.7

0.6

29 52/F

MFA

22.7 ± 2.3

25.4 ± 0.3

0.9

1.0

30 62/F

MFA

22.3 ± 0.2

23.0 ± 0.1

1.0

0.2

31 54/F

MFA

20.9 ± 0.7

25.8 ± 0.8

0.8

0.9

  1. F – Female; M – Male; HFC – Follicular carcinoma composed of Hürthle cells; FC – Follicular carcinoma; PC – Papillary carcinoma; HPC – Papillary carcinoma composed of Hürthle cells; mFA – Microfollicular adenoma; MFA – Macrofollicular adenoma; mMFA – Micro/macrofollicular adenoma; HmFA – Microfollicular adenoma composed of Hürthle cells; HMFA – Macrofollicular adenoma composed of Hürthle cells; Core I/Actin – Ratio between the expression of Core I gene and β-actin gene. *Values are expressed as ratio between the mean values obtained in tumours and normal tissues (previous columns). aResults are expressed as mean ± s.d. of three experiments. bOnly tumoural MIB-1 indexes are shown.