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Table 3 Univariate survival analysis of 20 CRC patients with liver metastases stratified by TS mRNA level and clinical response.

From: Thymidylate synthetase mRNA levels are increased in liver metastases of colorectal cancer patients resistant to fluoropyrimidine-based chemotherapy

 

Univariate analysis*

 

N (%)

HR

95% CI

Response

   

CR + PR

6 (30)

1

 

SD + PD

14 (70)

3.31

(1.06–10.32)

Chi-square; p value

χ2 = 4.24; p = 0.04

TS mRNA level

   

<13

10 (50)

1

 

>13

10 (50)

1.34

(0.52–3.44)

Chi-square; p value

χ2 = 0.48; p = 0.54

  1. *Cox proportional hazard ratio (HR) and corresponding 95% confidence interval (CI). Reference value.