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Figure 2 | BMC Cancer

Figure 2

From: Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells

Figure 2

Relative 5α-reductase (5αR) activities in MCF-7, MDA-MB-231, T-47D, and MCF-10A cells, calculated (mean ± SEM; n = 3–6) as (a) percent of total metabolites, (b) ratio of 5α-pregnanes:4-pregnenes, and (c) pmoles per hour per 106 cells of 5α-reduced metabolites produced. In (a) the mean levels of 4-pregnenes are significantly different from the mean levels of 5α-pregnanes at p < 0.001. In (b) and (c), *, **, and *** indicate significant differences from MCF-10A cells at p < 0.05, p < 0.01, and p < 0.001, respectively.

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