Skip to main content

Table 3 Mann-Whitney U Test comparisons of expression fold changes from SU5416 treatment and control arms (Trial A).

From: Expression profiling of blood samples from an SU5416 Phase III metastatic colorectal cancer clinical trial: a novel strategy for biomarker identification

 

P-value of Mann-Whitney U Test

Gene

Affymetrix

SYBR Green RT-PCR

 

(n = 23)

(n = 31)

MMP-9

0.0025

0.0748

Thrombospondin 1

0.0267

0.7186

CD24

0.0006

0.0057

Defensin α 3

0.0002

0.2196

Lactoferrin

0.0002

0.0065

Lipocalin 2

0.0005

0.0057

  1. Separate comparisons were performed on expression change values (predose day 56: predose day 1 ratios) from Affymetrix analysis and from SYBR Green RT-PCR validation experiments. P-values ≤ 0.05 were considered significant.