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Table 3 Multivariate adjusted* odds ratios by p53 status relative to polyp-free controls.

From: Tobacco, alcohol, and p53 overexpression in early colorectal neoplasia

 

No p53 protein overexpression (-)

p53 protein overexpression (+)

Case/Case comparison

(A) Associations using all cases (adenomas, CIS, IM)

Duration of Cigarette Smoking

   

   Nonsmoker

1.0

1.0

 

   < 15 years

1.5 (0.7–3.0)

2.1 (0.7–6.4)

1.5 (0.4–4.9)

   15 – 29 years

1.0 (0.5–1.8)

0.9 (0.3–2.8)

0.9 (0.3–3.1)

   30+ years

1.8 (1.1–2.9)

1.0 (0.4–2.6)

0.6 (0.2–1.5)

Pipes or cigars

   

   Never

1.0

1.0

 

   Ever

0.6 (0.3–1.2)

1.3 (0.4–4.0)

2.1 (0.7–6.9)

Beer Consumption

   

   Nondrinker

1.0

1.0

 

   1–7 bottles/week

1.5 (0.9–2.5)

0.4 (0.1–1.9)

0.3 (0.1–1.4)

   8+ bottles/week

1.6 (0.7–3.7)

4.0 (1.3–12.0)

2.5 (0.7–8.1)

Body Size

   

Body mass index (kg/m2)

   

   < 22.5

1.0

1.0

 

   22.5 – <25.5

1.2 (0.7–2.1)

1.2(0.4–3.5)

1.1 (0.4–3.3)

   25.5+

1.8 (1.0–3.1)

1.5 (0.6–4.2)

0.9 (0.3–2.5)

(B) Associations using all only cases with advanced adenomas (CIS and IM)

Duration of Cigarette Smoking

   

   Nonsmoker

1.0

1.0

 

   < 15 years

1.1 (0.4–2.8)

2.7 (0.8–9.6)

2.5(0.6–11.7)

   15 – 29 years

0.7 (0.3–1.7)

0.7 (0.2–2.7)

1.0 (0.2–4.5)

   30+ years

1.9 (1.0–3.5)

0.9 (0.3–2.8)

0.5 (0.2–1.7)

Pipes or cigars

   

   Never

1.0

1.0

 

   Ever

0.5 (0.2–1.2)

1.5 (0.4–5.5)

2.9(0.6–12.9)

Beer Consumption

   

   Nondrinker

1.0

1.0

 

   1–7 bottles/week

0.9 (0.4–2.0)

0.3 (0.04–2.4)

0.3(0.04–2.9)

   8+ bottles/week

1.4 (0.5–3.8)

4.1 (1.2–14.4)

3.0(0.7–13.2)

Body Size

   

Body mass index (kg/m2)

   

   < 22.5

1.0

1.0

 

   22.5 – <25.5

0.8 (0.4–1.7)

1.4(0.4–4.8)

1.7 (0.4–6.7)

   25.5+

1.3 (0.7–2.6)

2.2 (0.7–7.0)

1.7 (0.5–6.1)

  1. *age, age2, gender, race, and the other variables listed in the table.