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Table 2 Age adjusted odds ratios by p53 status relative to polyp-free controls.

From: Tobacco, alcohol, and p53 overexpression in early colorectal neoplasia

 

No p53 protein overexpression

p53 protein overexpression

Cigarette Smoking

  

   Never

1.0

1.0

   Former

1.3 (0.8–2.1)

1.1 (0.5–2.5)

   Current

1.7 (0.9–3.2)

1.6 (0.5–4.8)

Total number of years smoking*

  

   < 15 years

1.4 (0.7–2.7)

2.2 (0.8–6.4)

   15 – 29 years

0.9 (0.5–1.7)

0.9 (0.3–2.7)

   30+ years

1.8 (1.1–2.9)

1.1 (0.4–2.8)

Pipes or cigars

  

   Never

1.0

1.0

   Ever

1.0 (0.5–1.7)

1.6 (0.7–3.9)

Alcohol

  

Nondrinkers

1.0

1.0

Beer 1–7 bottles/week

1.6 (0.9–2.6)

0.4 (0.1–1.9)

Beer 8+ bottles/week

2.2 (1.0–4.7)

4.5 (1.6–12.4)

Wine (any wine during week)

1.2 (0.8–1.8)

0.8 (0.4–1.8)

Liquor (any liquor during week)

1.2 (0.8–1.8)

1.0 (1.0–4.2)

Total alcohol (wine+beer+liquor)

  

   1–13 drinks/week

1.1 (0.7–1.8)

0.8 (0.3–2.1)

   14+ drinks/week

1.5 (0.9–2.6)

2.4 (1.0–5.7)

Body Size and Physical Activity

  

Body mass index (kg/m2)

  

   < 22.5

1.0

1.0

   22.5 – <25.5

1.1 (0.8–2.3)

1.2 (0.5–3.7)

   25.5+

2.0 (1.2–3.3)

1.7 (0.7–4.3)

Leisure physical activity

  

   None

1.0

1.0

   2–4 hours/week

0.5 (0.2–1.4)

0.5 (0.1–3.5)

   5+ hours/week

0.8 (0.4–1.6)

1.3 (0.5–3.7)

Dietary variables

  

Fiber: < 12.5 grams/day

1.0

1.0

   12.5 – <17 grams/day

0.9 (0.5–1.5)

0.3 (0.1–1.1)

   17+ grams/day

1.1 (0.7–1.9)

0.9 (0.4–2.2)

Fat: < 60 grams/day

1.0

1.0

   60 – <85.5 grams/day

0.7 (0.4–1.2)

1.6 (0.6–3.9)

   85.5 grams/day

1.1 (0.7–1.8)

1.2 (0.5–3.3)