From: Tobacco, alcohol, and p53 overexpression in early colorectal neoplasia
No p53 protein overexpression (n = 125) | p53 protein overexpression (n = 32) | P value* | |
---|---|---|---|
Sex | |||
Male | 66(52.8%) | 16 (50%) | 0.77 |
Female | 59 (47.2%) | 16 (50%) | |
Age (μ μ ;± σ) | 65.7 (8.6) | 67.8 (9.5) | 0.23 |
Race | |||
White | 103 (83.1%) | 30 (93.8%) | 0.24 |
Black | 12 (9.7%) | 2 (6.2%) | |
Other | 9 (7.3%) | 0 (0%) | |
Family History of Colorectal Cancer | |||
Yes | 28 (22.4%) | 5(15.6%) | 0.40 |
No | 97 (77.6%) | 27 (84.4%) | |
Cigarette Smoking | |||
Nonsmokers | 43 (34.4%) | 12 (38.7%) | 0.90 |
Former Smokers | 61 (48.8%) | 14 (45.2%) | |
Current Smokers | 21 (16.8%) | 5 (16.1%) | |
Among smokers | |||
Age at Starting (μ ± σ) | 25.3 (11.3) | 29.6 (14.5) | 0.17 |
Total years (μ ± σ) | 29.2 (14.8) | 24.6 (16.3) | 0.23 |
Cigs per day (μ ± σ) | 24.7 (17.2) | 22.7 (20.2) | 0.66 |
Pipe or Cigar smoking | |||
Never | 106 (84.8%) | 25 (78.1%) | 0.40 |
Ever | 19 (15.2%) | 7 (21.9%) | |
Alcohol intake | |||
# of alcoholic drinks per week (μ ± σ) | 10.5 (15.6) | 12.6 (15.8) | 0.50 |
Other risk factors | |||
Body Mass Index (kg/m2) (μ ± σ) | 25.2 (4.3) | 25.6 (5.3) | 0.64 |
Leisure Physical Activity Hours/week (μ ± σ) | 0.6 (2.6) | 0.9 (1.9) | 0.69 |
Daily Fiber Intake Grams/day (μ ± σ) | 16.3 (6.9) | 16.1 (6.6) | 0.86 |
Daily Fat Intake Grams/day (μ ± σ) | 76.4 (39.4) | 69.7 (27.9) | 0.40 |
Polyp site | |||
Rectum | 19 (16.4%) | 9 (29.0%) | <0.01 |
Distal | 51 (44.0%) | 19 (61.3%) | |
Proximal | 46 (39.7%) | 3 (9.7%) |