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Table 7 Lung

From: Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis

Author

Cases N

Controlsa/Cohortb

Source Population

Exposure definition

Exposure assessment

Drug

RR

95% CI

Langman et al. [36]

2,560

7,643a

Population based

>7 prescriptions during months 13–36 before index date

Automated Database

NSAIDs (7%)

0.84

0.69–1.02

Harris et al. [51]

489

978a

Hospital based

>7 tablets per week during more than 2 years

Personal Interview

NSAIDs(26%)

0.32

0.23–0.44

Akhmedkhanov et al[54]

81

808a

Population based‡

>2 tablets per week during at least 6 months. 1 year lag time

Mailed Questionnaire

Aspirin (19%)

0.66

0.34–1.28

Moysich et al. [55]

868

935a

Hospital based

>1 tablet per week for at least 1 year

In hospital Questionnaire

Aspirin (18%)

0.57

0.41–0.78

Rosenberg[56]

1,110

4,906a

Hospital based

>3 days/week for >3 months 1.5 years of lag time

Personal Interview

NSAIDs (6%)

1.0

0.7–1.4

Paganini-Hill et al. [40]

111

13,987b

Cohort

Daily use of aspirin for an undefined time

Mailed Questionnaire

Aspirin (16%)

0.92§

0.54–1.55

Thun et al. [46]†

NR men

290,681b

Cohort

More than 16 times per month for at least one year

Mailed Questionnaire

Aspirin (11%)

1.11

0.98–1.25

 

NR women

344,350b

    

1.07

0.88–1.30

Schreinemachers et al. [43]†

163

12,668b

Cohort

Ever use of aspirin in the 30 days prior to start date

Personal Interview

Aspirin (59%)

0.68

0.49–0.94

  1. Prevalence of exposure among controls/cohort; †Respiratory (includes others); §Crude estimate calculated from data provided in the original manuscript; ‡Female population.