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Table 7 Lung

From: Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis

Author Cases N Controlsa/Cohortb Source Population Exposure definition Exposure assessment Drug RR 95% CI
Langman et al. [36] 2,560 7,643a Population based >7 prescriptions during months 13–36 before index date Automated Database NSAIDs (7%) 0.84 0.69–1.02
Harris et al. [51] 489 978a Hospital based >7 tablets per week during more than 2 years Personal Interview NSAIDs(26%) 0.32 0.23–0.44
Akhmedkhanov et al[54] 81 808a Population based >2 tablets per week during at least 6 months. 1 year lag time Mailed Questionnaire Aspirin (19%) 0.66 0.34–1.28
Moysich et al. [55] 868 935a Hospital based >1 tablet per week for at least 1 year In hospital Questionnaire Aspirin (18%) 0.57 0.41–0.78
Rosenberg[56] 1,110 4,906a Hospital based >3 days/week for >3 months 1.5 years of lag time Personal Interview NSAIDs (6%) 1.0 0.7–1.4
Paganini-Hill et al. [40] 111 13,987b Cohort Daily use of aspirin for an undefined time Mailed Questionnaire Aspirin (16%) 0.92§ 0.54–1.55
Thun et al. [46] NR men 290,681b Cohort More than 16 times per month for at least one year Mailed Questionnaire Aspirin (11%) 1.11 0.98–1.25
  NR women 344,350b      1.07 0.88–1.30
Schreinemachers et al. [43] 163 12,668b Cohort Ever use of aspirin in the 30 days prior to start date Personal Interview Aspirin (59%) 0.68 0.49–0.94
  1. Prevalence of exposure among controls/cohort; Respiratory (includes others); §Crude estimate calculated from data provided in the original manuscript; Female population.