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Table 5 Ovary

From: Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis

Author

Cases n

Controlsa/Cohortb

Source population

Exposure definition

Exposure assessment

Drug

RR

95% CI

Tzonou et al. [47]

189

200a

Hospital based

>2 tablets/week

Personal Interview

NSAIDs (26%)

0.51

0.26–1.02

Cramer et al. [28]

563

523a

Population based

>1 tablet/week for >6 months. 1 year lag time.

Personal Interview

Aspirin†(14%)

0.75

0.52–1.10

      

NSAIDs‡ (7%)

0.91

0.53–1.54

Tavani et al. [45]

749

898a

Hospital based

>1 tablet/week for >6 months. (current and/or former)

Personal Interview

Aspirin (6%)

0.93

0.53–1.62

Rosenberg[56]

448

4,906a

Hospital based

>3 days/week for >3 months 1.5 years of lag time

Personal Interview

NSAIDs (6%)

0.8

0.5–1.3

Rosenberg et al. [42]

780

2,570a

Hospital based

>4 days/week for at least 6 months.1 year lag time

Personal Interview

Aspirin (5%)

0.8

0.5–1.2

      

NA-NSAIDs (3%)

0.5

0.3–1.0

      

NSAIDs (8%)

0.7

0.5–1.0

Moysich et al. [37]

547

1,094a

Hospital based

>1 day/week for 6 consecutive months

In-hospital Questionnaire

Aspirin (12%)

1.00

0.73–1.39

Akhmedkhanov et al. [21]

68

680a

Population based

Ever use of >3 tablet/week for >6 months. 1 year lag time

Mailed Questionnaire

Aspirin (16%)

0.60

0.26–1.38

Meier et al. [61]

483

1,877a

Population based

≥30 prescriptions. 1 year lag time

Automated Database

NSAIDs (5%)

1.1

0.6–1.8

Fairfield et al. [50]

333

76,821b

Cohort

>1 tablet/week

Mailed

Aspirin (46%)

1.00

0.80–1.25

      

NSAIDs (N.R.)

0.60

0.38–0.95

  1. Prevalence of exposure among controls/cohort; †Over-the-counter only; ‡Prescription only.