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Table 2 Stomach

From: Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis

Author

Cases n

Controlsa/Cohortb

Source population

Exposure definition

Exposure assessment

Drug

RR

95% CI

Farrow et al. [30]

612

687a

Population based

>1 tablet/week during >6 months. 1 year lag time

Personal Interview

Aspirin (31%)

0.76

0.60–0.97

 

610

    

NA-NSAIDs (13%)

0.79

0.56–1.10

Akre et al. [22]

480

1,055a

Population based

>30 tablets/month. 2 years lag time

Personal Interview

Aspirin (3%)

0.8

0.7–1.1

      

NA-NSAIDs†

1.1

0.6–1.4

Zaridze et al. [48]

448

610a

Hospital based

>2 days/week for >6 months

In-hospital Questionnaire

Aspirin (14%)

0.60

0.41–0.90

      

NSAIDs (17%)

0.65

0.45–0.93

Langman et al. [36]

613

1,837a

Population based

>7 prescriptions during months 13–36 before index date

Automated Database

NSAIDs (8%)

0.51

0.33–0.79

Coogan et al. [26]

250

5,883a

Hospital based

>4 days/week for >3 months. Continuing use during 1 year of lag time

Personal Interview

NSAIDs (7%)

0.3

0.1–0.6

Thun et al. [46]

266

635,031b

Cohort

More than 16 times per month for at least one year

Mailed Questionnaire

Aspirin (11%)

0.53

0.34–0.81

Schreinemachers et al. [43]

39

12,668b

Cohort

Ever use of aspirin in the 30 days prior to start date

Personal Interview

Aspirin (59%)

0.93

0.49–1.74

  1. Prevalence of exposure among controls/cohort; †Exposure definition not provided.