Skip to main content


Figure 8 | BMC Cancer

Figure 8

From: Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line

Figure 8

Effect of I3C on cell number and intracellular spermine levels in SW480 cells after 24, 96 or 168 hour treatments. Cells were treated with DMSO alone (Con) or I3C as indicated, and intracellular spermine levels were determined by HPLC, as described in Materials and Methods. Results are presented as percentage of control values (mean n = 4; * indicates significant difference from control levels (P < 0.05); pooled SD = 0.8, 0.6, 1.1 and 24.4, 11.8, 12.0 for spermine levels and cell numbers respectively at 24, 96 and 168 hours). The mean spermine concentration (nmol/106 cells) in control cells at 24, 96 and 168 hr was 2.10, 1.25 and 0.76 respectively.

Back to article page