TY - JOUR AU - Hudson, E. Ann AU - Howells, Lynne M. AU - Gallacher-Horley, Barbara AU - Fox, Louise H. AU - Gescher, Andreas AU - Manson, Margaret M. PY - 2003 DA - 2003/01/14 TI - Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line JO - BMC Cancer SP - 2 VL - 3 IS - 1 AB - Many tumours undergo disregulation of polyamine homeostasis and upregulation of ornithine decarboxylase (ODC) activity, which can promote carcinogenesis. In animal models of colon carcinogenesis, inhibition of ODC activity by difluoromethylornithine (DFMO) has been shown to reduce the number and size of colon adenomas and carcinomas. Indole-3-carbinol (I3C) has shown promising chemopreventive activity against a range of human tumour cell types, but little is known about the effect of this agent on colon cell lines. Here, we investigated whether inhibition of ODC by I3C could contribute to a chemopreventive effect in colon cell lines. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-3-2 DO - 10.1186/1471-2407-3-2 ID - Hudson2003 ER -