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Figure 1 | BMC Cancer

Figure 1

From: Primary effect of chemotherapy on the transcription profile of AIDS-related Kaposi's sarcoma

Figure 1

Hematoxylin-eosin (H&E) staining of the AIDS-KS lesions used for SAGE Two skin biopsies were taken from a single patient, respectively 24 hrs (top panel) and 48 hrs (lower panel) after start of chemotherapy with doxorubicin, bleomycin and vincristine. In both biopsies, endothelial cell proliferations are seen in the dermis consistent with plaque stage Kaposi's sarcoma. The elongated nuclei of these cells show moderate atypia. Within the spindle cell areas, narrow slits containing erythrocytes are visible. Immunohistochemistry demonstrated that in both lesions the atypical spindle cells are CD31 and HHV8 positive (not shown). Additionally, in the upper panel, many apoptotic keratinocytes with nuclear dust are found scattered over the basal layer of the epidermis. This histologically visible therapy effect was not conspicuous any more after 48 hours. Both lesions contain sparse inflammatory cell infiltrates.

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