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Table 1 Effect of Aspirin Administration on Polyp Number and Area in Min/+ Mice.

From: Therapeutic utility of aspirin in the Apc Min/+murine model of colon carcinogenesis

 

Vehicle-Treated (n = 13)

Aspirin-Treated (n = 11)

 

Small

Large

Total

Small

Large

Total

Polyp Number

61 ± 9

1.9 ± 0.4

63 ± 9

62 ± 8

2.5 ± 0.4

65 ± 8

Polyp Area (mm 2 )

183 ± 70

8.7 ± 3.7

192 ± 73

159 ± 44

15.2 ± 5.5

174 ± 47

Polyp Diameter (mm)

1.6 ± 0.2

1.8 ± 0.5

NA

1.7 ± 0.1

2.4 ± 0.5

NA

  1. Min/+ Mice were treated orally with either vehicle or aspirin (25 mg/kg) once daily for 28 days, commencing at 12 weeks of age. Data are expressed as the mean ± SEM. Groups of data were compared using an unpaired t test. Analysis revealed no statistically significant difference between the treatment groups. NA = Not Applicable