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Table 2 Concentration of mhATF-BPTI in the subcutaneous tumours

From: Adenoviral gene transfer of angiostatic ATF-BPTI inhibits tumour growth

  

L44

L42

Route of administration

n

Day 7

Day 14

Day 7

Day 14

Intravenous [ng / g tumour]

6

1791 ± 274

1256 ± 187

162 ± 98

152 ± 34

[ng / ml plasma]

 

(658 ± 56)

(506 ± 62)

(52 ± 23)

(61 ± 21)

Intratumoral [ng / g tumour]

6

59 ± 35

88 ± 34

1415 ± 147

1048 ± 485

[ng / ml plasma]

 

-

-

-

-

  1. The concentrations were determined after a single iv injection of 1010iu Ad Adapt mhAB and after intratumoral injection of Ad Adapt mhAB (1010iu / day for 3 days). The concentration of mhATF-BPTI [ng / g of fresh tissue] was determined in the tumour lysate at 7 and 14 days after the vector delivery. The plasma concentration [ng / ml] is indicated under the intra tumoral values. In case of the intra tumoral administration the plasma levels were under the detection limit.
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BMC Cancer

ISSN: 1471-2407

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