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Table 1 Doubling time and vascularisation of the tumours

From: Adenoviral gene transfer of angiostatic ATF-BPTI inhibits tumour growth

 

N

L44 adenocarcinoma

L42 squamous cell carcinoma

Rat strain

 

Brown Norway

Wag/Rij

Volume Doubling time

   

   • in vitro [hours]

4

19.3 ± 1.9

46.2 ± 5.7

   • subcutaneous tumour [days]

10

3.5 ± 0.5

8 ± 0.7

   • lung metastasis [days]

10

3.9 ± 0.3

9.9 ± 0.7

MVD [%] ± SD

   

   • subcutaneous tumour

5

3.5 ± 0.1

2 ± 0.1

  1. The in vitro doubling time is determined after two days of culture of 106 cells / well in a 6-wells plate. The Volume Doubling Time of subcutaneous tumours is assessed between 1000 and 2000 mm3. For the lung metastasis the doubling time was determined between day 11 and 22 for the L44 and between day 20 and 53 for the L42 carcinoma. The micro-vascular density (MVD) represents the surface of all endothelial cells as percentage of the surface of non-necrotic tissue. This was measured in 10 × 10 × 10 mm subcutaneous tumours. The values indicate means ± SD.
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BMC Cancer

ISSN: 1471-2407

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